1,4‐Benzoquinone forms an unstable thioether bond with cysteine residues that is eliminated in basic conditions
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چکیده
منابع مشابه
Role of cysteine residues in human angiotensinogen. Cys232 is required for angiotensinogen-pro major basic protein complex formation.
The M235T polymorphism of human angiotensinogen is associated with essential and pregnancy-induced hypertension. A covalent complex is formed between angiotensinogen and the proform of the eosinophil major basic protein (proMBP) during pregnancy. The sequence of human angiotensinogen contains four cysteines. Their function was analyzed. Presence of free cysteines was demonstrated by their alkyl...
متن کاملAssembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.
Cysteine residues 110 and 187 are essential for the formation of the correct bovine rhodopsin structure (Karnik, S. S., Sakmar, T. P., Chen, H.-B., and Khorana, H. G. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 8459-8463). We now show that the sulfhydryl groups of these 2 cysteine residues interact to form a disulfide bond. Rhodopsin mutants containing cysteine----serine substitutions were prepa...
متن کاملHighly reactive cysteine residues in rodent hemoglobins.
Two hemoglobins with cysteine residues highly reactive toward electrophiles have been identified and characterized. Cys-125beta of guinea pig hemoglobin has a low pK(a) and forms conjugates with electrophiles more quickly than glutathione and several orders of magnitude more quickly than other protein thiols. This cysteine is capable of intercepting benzoquinone, a known carcinogenic metabolite...
متن کاملReaction of SchifPs reagent with the partially-oxidized forms of metallothionein and other polypeptides rich in cysteine residues
The major route of elimination of 14C was the urine, with 50% of the dose excreted by the chimpanzees, 38% by the rhesus monkeys and 56% by the galagos. Less than 1% of the dose was recovered in the faeces of all three species. Details of the urinary metabolites are given in Table 1. In all cases, caffeine was very extensively metabolized, accounting for less than 1% of urinary radioactivity in...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.1131.6